KELAINAN PERKEMBANGAN KRANIOFACIAL FETUS MENCIT (Mus musculus L.) Strain DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.)
Abstract: The purpose
of this study
is to investigate
the effect of
n-hexane extract of
andaliman (Zanthoxylum acanthopodium
DC.) fruit on craniofacial development of DDW Mice (Mus musculus L.).
Experiment was carried out using
Completely Randomized Design
(CRD) with 5
treatments and 6
replicates. Treatments consist
of a blank control,
vehicle control (1%
CMC) and 3
concentrations of andaliman
extract (2%, 4% and 6%). All treatments were administered
by oral gavage (0.1 ml/10 g bw) once
daily from day 0 to day 10 of
gestation. N-hexane extract
of andaliman fruit induced
developmental abnormalities in craniofacial
structures i.e. increased the incidence
of microphthalmia (P
<0.05), and hydrocephalus
(P <0.05). In conclusion, we suggested that andaliman
fruit may have fetotoxic effects.
Keyword: andaliman
(Zanthoxylum acanthopodium DC.), micropthalmia, hydrocephalus
Penulis: Mai Sarah, Emita Sabri
dan Salomo Hutahaean
Kode Jurnal: jpbiologidd120003
