PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS TESTIS MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG)
Abstract: The
aim of this study is to determine the effect of vitamin C and E on testicular histology of mice following exposure
to monosodium glutamate (MSG) for 30 days. Completely Randomized Design (CRD)
consisting of 6 treatments and 5 replications was used in this experiment. Mice
were treated daily by oral gavage with 4 mg MSG (P1), 4 mg MSG + 0,26 mg vitamin C (P2), 4 mg MSG + 0,026 vitamin E (P3), and 4 mg
MSG + 0,26 mg vitamin C + 0,026
mg vitamin E (P4). All dosages (mg/g) were given based on body weight. Two control groups
K- and K+
treated with water
and castor oil
respectively. The results
showed that MSG decrease testis weight and its volume
(P<0,05), MSG also decrease the diameter of seminiferous tubule and the
number of spermatogenic cells. Vitamin C recovers testis weight (P<0,05),
but cannot recover its volume, diameter
of seminiferous tubules
and the number
spermatogenic cells (P>0,05).
Vitamin E increases
the weight and volume
of the testes
and spermatogenic cells
(P<0,05), but unable
to recover diameter
of the seminiferous tubules
(P>0,05). The combination
of vitamin C
and E recover
testis weight and
its volume, seminiferous tubule
diameter and number of
spermatogenic cells (P<0,05).
Keywords: Monosodium
Glutamate, Vitamin C, Vitamin E, Testis
Penulis: Ummi
Kalsum, Syafruddin Ilyas dan Salomo Hutahaean
Kode
Jurnal: jpbiologidd130013
