PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS GINJAL MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG)
Abstract: The aim of this
research is to study the effect of
vitamin C and E on kidney microstructure of
mouse exposed to monosodium
glutamate for 30
days. This research
used complete randomized
design which consisted of 6
treatments and 5 replications. The control consisted of K-, and K+ (castor oil 0.3 ml). The treatments
were MSG 4 mg/g BW, P1 (only MSG), P2 (MSG plus vitamin C 0.26 mg/g BW), P3
(MSG plus vitamin E 0.026 mg/g BW) and P4 (MSG plus vitamin C and E). After
treatments were completed, the mice were sacrificed by cervical dislocation,
and kidney tissue section was prepared by
the paraffin method and stained
with Haematoxylin and Eosin staining. Microstructure damage of kidneys showed a
significant difference between control and treatments. In P1, the proximal
tubule damage was 69.95%±5 and in P4 was 47.22%±3. In summary MSG can cause
damage in the form of a narrowing of the lumen of the proximal tubules of the
kidney. A combination of vitamins C and E can reduce the effect of MSG on the
kidney.
Keywords: kidney, Monosodium
glutamat (MSG), Vit C, Vit E
Penulis: Zulfiani, Syafruddin
Ilyas dan Salomo Hutahaean
Kode Jurnal: jpbiologidd130038
