PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS HEPAR MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG)
Abstract: This study aimed to determine
the effects of vitamin C and E on liver microstructure of mouse
exposed to monosodium glutamate (MSG) for 30 days. The experiment
used completely randomized
design which consists of 6
treatments and 5 replications. Mice were
treated daily by oral gavage with 4 mg MSG (P1), 4 mg MSG + 0.26 mg vitamin C (P2), 4 mg MSG + 0.026 vitamin E (P3), or 4 mg
MSG + 0.26 mg vitamin C + 0.026
mg vitamin E (P4). All dosages were based on mg/g body weight. Two control
groups K- and K+ were treated with water and castor oil respectively. The mice
liver tissue slide was prepared by the paraffin method and
stained with haematoxylin-eosin (HE).
The results showed
that MSG caused
cell degeneration and necrosis in
liver tissue. Vitamin C and E was able
to recover liver cell damage induced by
MSG. The highest result
was found in P3
and combination treatment (P4)
where the recovery effect reaches 64% and 80% respectively.
Keywords: Liver, Monosodium
glutamate (MSG), Vitamin C, Vitamin E
Penulis: Ahri Maulida,
Syafruddin Ilyas, Salomo Hutahaean
Kode Jurnal: jpbiologidd130041
