DAYA ANTELMINTIK EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP CACING Ascaridia galli SECARA In Vitro DAN PROFIL KLTNYA
ABSTRACT: People used noni
leaf (Morinda citrifolia L.)for medication many kinds disease, one of as
anthelmintic. Worm infection most generally in the world, especially in growing
countries including indonesia. To prove the truth were efficacious noni leaf as
anthelmintic has been research anthelmintic capability ethanol extract of noni
leaf on the worm Ascaridia galli on in vitro. This research has done by using
Lamson and Brown method submerges that has been modified. Research using 270 of
worms A. galli female, that devided into 9 groups, that’s 4 groups treatment
with ethanol extract of noni leaf in consentration of 20 mg/mL, 30 mg/mL, 40
mg/mL and 50 mg/mL, 4 groups positive control (citrate piperazin) consentration
2 mg/mL, 4 mg/mL, 6 mg/mL dan 8mg/mL and I group negative control (NaCl 9
mg/mL) each group consist of 6 petri disc (each petri disc contain 5 of worms
and 25 ml solution). Anthelmintic capability showed with worm mortality time
that’s observed every 2 hours and LC50 that needed consentration to wipe out
50% of worm. The result of this research shown rates worm mortality time after
submerges with ethanol extract of noni leaf consentration 20 mg/mL, 30 mg/mL,
40 mg/mL and 50 mg/mL as hight as 48,00 ± 1,79 ; 44,33 ± 1,51; 40,33 ± 1,51;
36,00 ± 2,53 (hours). But after submerges with citrate piperazin 4 mg/mL is
34,33 ± 1,51 (hours). LC50 after submerges ethanol axtract of noni leaf is
50,21 mg/mL and after submerges 2,27 mg/mL. The result of the observed Thin
Layer Chromatography (TLC) shown ethanol extract of noni leaf containes
compounds from flavonoid and fenol. Based on result of the reseach would be
concluded that ethanol extract of noni leaf contain compounds that calculate
have anthelmintic activity, possibilty that’s compounds is flavonoid and fenol.
Keyword: Morinda citifolia L.
, anthelmintic, submerges of Lamson and Brown
Penulis: Riyanta aribawa, Anis
wihdayanti, Mustofa
Kode Jurnal: jpfarmasidd080029
