ABSTRACT: Increasing age is
generally followed by increasing chronic diseases so that the elderly needs
much therapy using drugs for therapy of numerous diseases they have.
Hyper-tension is one of diseases of which its prevalence increases along with
increasing age. Most of the elderly diagnosed as having hypertension finally
take therapy using anti-hypertension drugs. Physiological changes that happen
to the elderly lead to use of drugs for side effect diseases of which their
consumption should be considered while having anti-hypertension drugs. Changes
in biological system to the elderly will af-fect the process of drug molecular
interaction, which finally affects clinical efficacy and pharmacotherapeutic
safety. Meanwhile, minimizing the problem of drug use insecurity is one of good
prescription demands in the implementation of clinical pharmacy. To identify
and study safety of anti-hypertension drug use at the elderly polyclinic of Dr.
Sardjito Hospital Outpatient Installation by identifying and evalu-ating
contraindication, interaction and side effect of anti-hypertension drugs. This was
a descriptive study with data taken prospectivelly from 80 patients of the
elderly polyclinic of Dr. Sardjito Hospital Outpatients Installation from
November 14 to December 13, 2005. Data were obtained from medical records,
interviews and ques-tionnaires. The study on contraindication, interaction and
side effect of drugs which happened was based on a guideline book. There was
27.5% of patients took anti-hypertension drugs which were not beneficial to
patients’ clinical condition, so the that use of antihypertension drugs needs
monitoring. As much as 41.3% of patients took combined drugs potential to cause
interaction, 8.7% of which had clinical symp-toms presumed to be related with
possibility of increasing drug interaction effect. As much as 33.8% of patients
had at least one drug side effect considered to be related or possibly related
with anti-hypertension medication. Use of anti-hypertension drugs among the
elderly had not been relatively safe because there was drug combination potential
of causing interaction, light drug side effect and the possibility of
contrain-dication due to use of anti-hypertension drugs which was not
beneficial to patients’ clinical condition so that monitoring to use of
anti-hypertension drugs was needed.
Keywords: elderly,
hypertension, contraindication, interaction, drug side effect
Penulis: Zullies Ikawati, Sri
Djumiani, I Dewa Putu P.S
Kode Jurnal: jpfarmasidd080003
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