ABSTRACT: The effect of
carnauba wax consentration to pharmacotechnical characteristics on the granules
and tablets that made by hot melt granulation method have been studied. Fomula
I? V with composition : 10, 20, 30, 40, and 50% w/w carnauba wax, propranolol
hydrochloride 60 mg/tablet, and lactose to the 340 mg was mixed and melted, and
than sieved to the mesh 16 siever. The granules were evaluated and lubri-cated
by 1% magnesium stearat and 2% talcum. Then it were compressed into tablet which
each weight was 350 mg and the tablets were evaluated. The results showed that
hot melt granulatin form granules and tablets that acceptable pharmacotechnical
properties.
Keywords: carnauba wax, hot
melt granulation, matrix, pharmacotechnical
Penulis: Ilma Nugrahani, Hasan
Rahmat, Joshita Djajadisastra
Kode Jurnal: jpfarmasidd050008
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