PATI PREGEL PATI SINGKONG FOSFAT SEBAGAI BAHAN PENSUSPENSI SIRUP KERING AMPISILIN
ABSTRACT: For most reason for
dry suspension is the drug changes from chemical degradation or hydrolysis like
ampicillin. The dry syrups that require mixing prior to ad-ministration is
solving the problem. These suspension are commercial, dry mixtures that require
the addition of water at the time of dispensing. Many antibiotics are formulated
as dry syrups and are intented for a pediatric patient population. There are
usually fewer suspending material in suspension dry syrup than in convensional suspensions.
The criteria for selecting inggredients are based both on suitable reconstitution
and on physical tipe of powder mixture desired. This research was carried out
the possibility of using phycical and chemical modification of cassava starch as suspending material.
First, pregelatinized cassava starch was
made by heated the cassava starch with added amount water. Secondly,
phosphorylated by adding phos-phorous
oxychloride for making cross-linked
reaction and adding sodium mono-hydrogen
phosphate (Na2HPO4) for making substituted reaction respectively. Both of the cassava starch phosphate derived
was used in tree formulas dry syrup, as comparative suspending material was Na
Alginate. Then dry syrup was evaluated accordance to
Indonesian Farmacopea ed IV included
sedimentation volume, redispersion, viscosity, flowing properties, pH,
and ampicillin content after seven days. The result of evaluation were particle
size 355-500 µm, flow rate 2,7-4,6 g/det.
Sedimention volume at temperature 27ºC
during seven days for all formulas were 0,8-1,0, and redispertion 3-5 times.
The viskosity of the suspensions were 58,6-357,1 cps .Flowing properties of the
liquids were plastis -plastis tixotropic, pH
4,97-5,21, and ampicillin content
between 93,12-99,00%.
Keywords: dry syrup,
pregelatized cassava starch phosphate, ampicillin
Penulis: Effionora Anwar, Antokalina
SV, Harianto
Kode Jurnal: jpfarmasidd060005
