ABSTRACT: The human population
is heterogeneous and consists of populations of immense ethnic diversity. There
are considerable allelic differences between human populations as well as
individuals within each ethnic group as a result of molecular hetero geneity of
the genome. This, in turn, is responsible for differential allelic expression of
genes endowing them with polymorphic characters. The molecular diversity within
genes is responsible amongst others, of disease resistance or susceptibility or
for that matter drug response. Pharmacogenomics is the key to the understanding
of differential drug response in different patients in relation to genetic
constitution. The revelation of such information at the molecular level would
assist the pharmaceutical industry to address a therapy directed to each
individual. The objective of this article is to understand the nuances of the
genetic repertoire and correlate it with disease gene identification, genes
that have been or can be used as drug targets, identify candidate genes for
drug development and recent trends in drug discovery.
Penulis: Maksum Radji
Kode Jurnal: jpfarmasidd050015
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