ABSTRACT: The determination of
triprolidine hydrochloride and pseudoephedrine hydro-chloride in anti influenza
tablet has been performed using derivative spectrophotometry method.
Triprolidine hydrochloride and pseudoephedrine hydrochloride were determined by
measuring the first derivative ratio amplitudes, at 227,6 nm (zero crossing for
pseudoephedrine hydrochloride) and at 230,0 nm (zero crossing for triprolidine
hydrochloride) respectively. The linear calibration graphs were obtained for
5-50 ppm of triprolidine hydrochloride and for 100-800 ppm of pseudoephedrine hydrochloride.
The results showed that the method is rapid, simple and can be applied
successfully to assay simultaneously of two components in tablet preparation.
Keywords: triprolidine
hydrochloride, pseudoephedrine hydrochloride, de-rivative spectrophotometry,
zero crossing
Penulis: Hayun, Harianto dan
Yenti
Kode Jurnal: jpfarmasidd060007
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