ABSTRACT: Asetil salisilat
acid or known as acetosal or aspirin is a class of analgetic and antipyretic
medicine that used widely. In this research we used acetosal to know it
stability for sucrose effect. Acetosal stability examination of temperature
effect and pH that done in several sucrose concentration, they are 5,0 %; 10,0
%; and 15,0 % which pH 7,0; 8,0; 9,0 and 10,0 in the 40 0C, 50 0C and 60 0C.
The result of research showed that acetosal degradation reaction the sucrose
fluid in pH 7,0; 8,0; 9,0 and 10,0 at the 40 0C can speedyacetosal degradation
where the speed degradation with sucrose effect has more higher value than the
degradation without sucrose effect, while in the 50 0C and 60 0C sucrose made
stability of acetosal where degradation value with sucrose effect that smaller
than degradation speed without sucrose effect.
Key words: asetosal,
stability, sucrose
Penulis: Ifiet pantilata, Suwaldi
suwaldi
Kode Jurnal: jpfarmasidd070011
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