ABSTRACT: The research to
accelerate furosemide dissolution rate has been done through physical property
modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with
solvent method. Pure furosemide posses property of being practically insoluble
in water and has low bioavailability. In current research, six weight ratio of
furosemide to PVP being used are 1:1; 1:3; 1:5; 1:9 and 1:15. Physical mixtures
are made in equivalent weight ratio. The dissolution rate was examined by
paddle method in phosphat buffer pH 5,8. Solid dispersion caracterised with in
vitro disso-lution study, X-ray diffraction, infra red spectrophotometer and
differential scan-ning calorimetric. The result shows that solid dispersion of
furosemide with PVP carrier is higher compare to physical mixture dissolution
rate and pure furosemide. The ratio furosemide to PVP who has the highest
dissolution rate is 1:15. The ana-lyzing shows the existing of altering
crystalline to amorphous state.
Key word: furosemide,
polyvinylpyrolidone, solid dispersion, dissolution rate
Penulis: Sutriyo, Rosmaladewi,
Febrian Hevike Filosane
Kode Jurnal: jpfarmasidd050013
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