ABSTRACT: Amoxiciilin is an
antibiotic of penicillin. It has been used to treat bacterial infections that
caused by Gram negative bacteria and Gram positive bacteria. Most of
amoxicillin tablet has been sold with generic name and non generic name. This research
was proposed to compare quality and price of amoxicillin tablet 500 mg at the
drug store. Especially, for amoxicillin tablet 500 mg generic and non generic. Determination
of quality amoxicillin tablet could be showed from standard quality of
amoxicillin tablet was based at USP XXVI. Identification, dissolution and assay
were included standard quality of amoxicillin tablet. Identification test was
per-formed by TLC with mobile phase consist of methanol, chloroform, water and
pyridine (90:80:30:10). Assay of dissolution test was performed by HPLC with
mobile phase potassium dihydrogen phosphate buffer and acetonitrile (39:1).
Assay of tablet was performed by HPLC with mobile phase potassium dihydrogen
phosphate buffer and acetonitrile (96:4). The experiment was held to 15 brands
of tablet which they had consisted 3 brands of generic tablet and 12 brands of
non generic tablet. The test resulted that every brands of tablet fulfilled
standard quality of amoxicillin tablet. But in the test, there was variation of
price, in ordinarily price of non generic tablet was more expensive than
generic tablet.
Key words: amoxicillin; generic; non generic;
penicillin; standard quality
Penulis: Harianto, Sabarijah
W., Fitri Transitawuri
Kode Jurnal: jpfarmasidd060004
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