ABSTRACT: Chitosan is a
polycatonic biopolymer that can form gel in acidic environment so that can be
used as a hydrophilic matrix in controlled release drug delivery system. In this
research, propranolol hydrochloride controlled release granule was made in chitosan
matrix. Granules were made by wet granulation method with variety of matrices,
i.e. chitosan, hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC).
HPMC and EC were used as a comparing matrix. The release rates of propra-nolol
HCl from matrix were determined by using dissolution apparatus type I with 50
rpm stirring rotation in acidic media of pH 1,2 and base media of pH 7,5 for 8 hours.
Sample was taken at certain time and the samples were analyzed by
spectro-photometer. The result showed that the release of propranolol
hydrochloride from chitosan matrix was the slowest compared to the other
matrices.
Key words: chitosan; matrix;
propranolol HCl; controlled release granule
Penulis: Sutriyo, Joshita D.,
Rosari Indah
Kode Jurnal: jpfarmasidd050004
Artikel Terkait :
