ABSTRACT: Some diseases, such
as cancer, hereditary and genetic diseases, as well as viral infectious
diseases, have been treated unsatisfied by the conventional therapy so far, and
even more, by the gene therapy. Together with the pharmaceutical industries, researchers
put their best effort to hunt some molecules that can be more favorable for such
kind of therapy. After a pivotal study reported in May, 2001, it is certain
that Ribonucleic acid (RNA) could effectively silence gene expression in
mammalian cell line, so it was then proposed in 2004 the term RNA therapeutics.
Antisense RNA therapy which came into the stage earlier seemed to be the one
that can answer all the problems in knocking out the unwanted messenger in gene
expression. RNA interfer-ence (RNAi) concept, which came later in around 2000,
began to look like a possible contender. It was reported in some studies that
RNAi seems to have some more advan-tages over both stronger gene-silencing
effects and greater ease of use. However, the main obstacle of all kind of gene
therapy is, undoubtedly, on the delivery of this molecule to enter the target
cell, and mostly, to where it is needed most inside the body. Some studies on
genetic material delivery system have been reported, and their progress has
been discussed.
Keywords: RNA therapeutics,
antisense RNA, siRNA, terapi gen, gene silenc-ing.
Penulis: Amarila Malik
Kode Jurnal: jpfarmasidd050011
Artikel Terkait :
