ABSTRACT: Many type of starch
from various plants can be exploited as an alternative for additional materials
in tablet formulation. One of the source that have been developed as a
pharmaceutical excipient is durian seed starch, which relatively easy to find
in tropic area such as Indonesia. The objective of this research was to observe
the ability of durio seed starch as binder in wet granulation of ketoprofen
tablet formulation. Durio seed starch obtained by extraction and drying
methode. Starch as a paste used in wet granulation as a binder. Tablet made by
wet granulation with ketoprofen (25%) as a drug model; calcium phosphate
dihidrate as a diluent; Avicel® PH 102 as a disintegrant; magnesium stearat
(1%) and talc (2%) as a lubricant. Placebo formula with various durio seed
starch concentration (5%, 6%, 8%, 10%) in tablet compared to other binder that
is cassava starch. Placebo tablet formula with better hardness and friability
used in ketoprofen tablet formula and compared to cassava starch as a binder
with the same concentration. Formula with durio seed starch as binder have
smaller hardness and more friable than cassava starch as a binder. Thereby
tablet with durio seed starch as binder have faster disintegration time than
tablet with cassava starch as a binder. The dissolution test for both
ketoprofen formula did not meet the pharmacopeial requirements.
Key words: durio, starch,
ketoprofen
Penulis: Mahdi Jufri, Rosmala
Dewi Akhmad Ridwan Firli
Kode Jurnal: jpfarmasidd060008
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