ABSTRACT: Various
solubilization techniques have been developed to enhance the bioavailability of
hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion.
Microemulsion is a potential carrier in drug delivery system because it has
many advantageous characteristics. In this research, hydrophobic drug was made
in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model
and investigated the influence of adding starch hydrolisates with dextrose
equiva-lent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to
the stability of this microemulsion system. This microemulsion consisted of
isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol
as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as
stabilizer, and water as external phase. The evaluation was stability test both
phisically and chemically. The result showed that the stability of
microemulsion system increased significantly by adding starch hydrolisates DE
35-40 at 2,5%.
Key words: microemulsion,
ketoprofen, starch hydrolisates
Penulis: Mahdi Jufri,
Effionora Anwar, Putri Margaining Utami
Kode Jurnal: jpfarmasidd060014
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