PENGARUH PEMBERIAN EKSTRAK BUAH MERAH (Pandanus conoideus) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) DIABETIK
ABSTRAK: This research was
conducted to determine the effect of extract of buah merah (Pandanus conoideus)
on blood glucose levels in rats (Rattus norvegicus) diabetic. The samples used
were 20 male Wistar rats, aged 2 months and weighed 160-180 grams were divided
into four groups randomly each of five rats. I as a normal control group were
given distilled water, 1 ml / head / day / orally, group II as control of
alloxan, alloxan injected dose of 140 mg / kg bw / ip on day 2, group III were
injected with alloxan 140 mg / kg bw / ip on day-to-two, was given a dose of
buah merah extract 4 g / kg bw / day / orally day 3 until day 21, group IV
injected with alloxan dose of 140 mg / kg bw / ip on days 2 and extract buah
merah dose 17 g / kg bw / day / orally day 3 until day 21. Blood glucose levels
checked for day-to-0, 3, 6, 10, 14, and 22. Blood glucose data were analyzed
statistically by using analysis of variance (ANOVA) of One Way Anova, followed
by the Tukey-test and LSD test. The results after 24 hours were given alloxan
(day 3) an increase in blood glucose levels significantly (p <0.05) in group
II, III, and IV compared with group I (control). After treatment with buah
merah extract in group III and IV decreased glucose levels (p <0.05) on day
6 until the last day of the study (day 22).From the research, buah merah
extract dose 4 g / kg bw / day / orally and 17 g / kg bw / day / orally can
decrease blood glucose levels in diabetic rats (p <0.05).
Keyword: aloksan, diabetes
melitus, extract of buah merah, blood glucose
Penulis: R. FEBRIYANTI
Kode Jurnal: jppeternakandd110009
