Mastosit Perivaskuler Berperan Sebagai Vasodilator Pembuluh Darah pada Mesenterium Tikus
ABSTRACT: Mastocyt degranulated
can cause vasodilatation of
blood vessels, but
it is unclear
whether there is a relationship
between the number of mastocyt with a diameter of blood vessels. This study
aims to determine the relationship between the number of mastocyt pherivascular
and diameter of blood vessels. This research is in vivo exploratory research
in Wistar rat mesentery which was
sensitated with ovalbumin. The diameter of blood vessels at mesentery preparate
were measured microscopically using a micrometer scale standards. At large
diameter of blood vessels (2.860 ±
0.348), the number of mastocyt was 12.3 ± 2.3. At medium diameter of blood
vessel (1.276 ± 0.198), the number of mastocyt was 4.4 ± 0.5. Blood vessels
with small diameter (0.961 ± 0.043), the number of mastocyt was 3.5 ± 1.3.
Calculations area on the microscope visual field was divided into four areas
(counting area), there were zone 1, zone 2, zone 3 and zone 4. Statistical
analysis showed that the correlation between the number of mastocyt at zone 1 and the diameter of blood vessels was 0,904
at 1% significance level. Similar to that at zone 2 (r=0,892), zone 3 and zone
4 (r=0,940). We conclude there was a significant relationship between the
number of mastocyt and the diameter of blood vessels.
Penulis: Mohamad Nur Ibrahim,
Miftahu Soleh, Edi Widjajanto
Kode Jurnal: jpkedokterandd090149
