Mekanisme Toksigenitas Molekuler dan Potensi Medik Toksin Difteri
Abstract: Diphtheria is a very
acute contagious and acute upper respiratory tract infection caused by
toxigenic strain Corynebacterium diphtheriae. The characteristic pseudomembrane
may cause respiratory obstruction, so untreated infection can be fatal.
Pathogenesis of Corynebaterium diphtheriae begins with colonization of the
upper respiratory tract, followed by production of exotoxin which inactivate
EF-2, consequently protein synthesis is block completely and irreversibly,
causing cell death. Regulation of diphtheria toxin is controlled by dtxR gene
in bacteria activated by Fe system. Nowadays, diphtheria toxin has been
introduced as a new method in cancer therapy. Diphtheria toxin can be modified
by substitution or germline engineering so that its toxicity is aimed only to
cancer cells.
Penulis: Djaja Rusmana, Endah
Tyasrini, Inggreat Limmargo
Kode Jurnal: jpkedokterandd060046
