Pengobatan Suportif Vitamin D Mempercepat Konversi Sputum dan Perbaikan Gambaran Radiologis Penderita Tuberkulosis
ABSTRACT: Pulmonary
Tuberculosis remains as a major health problem in South East Asia as well as
Indonesia. The failure of tuberculosis treatment is mostly due to drop-out and
multiple drugs resistant. Previous study showed that Vitamin D increase the
intracellular cathelicidin which has potency to kill the Mycobacterium
tuberculosis. This research was aimed to identify the effect of Vitamin D as
supportive treatment on the improvement
of sputum conversion, radiographic finding and TNF-α serum concentration. A
Double-blind randomized control trial was used in two random allocated patient
group with standard tuberculosis treatment.
The first group was treated with Vitamin D (800 iu/day) while the other
was not. Subjects were evaluated using three parameters i.e. sputum conversion,
radiographic finding and TNF-α serum concentration. Compared to the group
without vitamin D supplementation, group with vitamin D has higher proportion
of sputum conversion in the first month (67% vs. 34%, p=0,04) and second month (95% vs.
77%, p=0,18). Improvement in
radiographic findings in the group with vitamin D is also higher in the first
month (67% vs. 18%, p=0,02) and second month (76% vs. 45%, p=0,06). There is a significant difference in the
level of 25-dihidroxyvitamin D between two groups (p=0,00). However, there is
no significant difference in the level of TNF-α between two groups (p=0,76)
after two months. Vitamin D has supportive effects in pulmonary tuberculosis
patients by improving healing process as indicated by faster improvement in
sputum conversion and radiographic findings but it did not improve the decrease
of TNF-α.
Penulis: Siswanto, Sumarno,Yani
Jane, Oeryana Agustin Widayanti, Nunuk
Sri Muktiati
Kode Jurnal: jpkedokterandd090147
