INTERVENSI ISOFLAVON KEDELAI TIDAK BERPENGARUH TERHADAP STATUS INFLAMASI DAN IMUNITAS PADA REMAJA DENGAN KEGEMUKAN
ABSTRACT: Overweight/obesity
is a condition that has been proven to be interrelated with chronic inflammation
and compromised immune system due to disregulation of adipocytokine. The aim of
the present study was to evaluate the effect of soy isoflavone on the markers
of inflammation and immunity of overweight or obese teenagers. Eighteen
overweight or obese teenagers, 9 boys and 9 girls each sex were randomized to
one of three intervention groups; 0 ml,
150 ml and 300 ml soy milk, equal to 0 g, 25 g and 50 mg isoflavone everyday
for 30 days. The data collected were food consumption, plasma isoflavone concentration,
plasma IL6 as indicator of inflammation, and lymphocyte and NK cell count as
indicator of immunity. The study showed that nutrient intake of samples were
still relatively low. The soy milk intervention significantly increased plasma
isoflavone concentration, but not significantly had contribution to the plasma
IL6 concentration and lymphocyte and NK cell count. Several kind of food
consumed by samples had contribution to the plasma isoflavone concentration,
and lymphocyte count. Based on the results, it was suggested that soy
isoflavone intervention does not affect the inflammation status and immunity of
overweight/obese teenagers.
Penulis: Mira Dewi, Ali
Khomsan, Dadang Sukandar
Kode Jurnal: jpkesmasdd100109
