Tidak ada perbedaan respon imun perokok berat dan perokok ringan karena asupan mikronutrien
Objectives: This study
aimed to analyze the difference in levels of cytokines (IFN-γ, IL-6 and IL-10) based on the degree of
smoking, and how the daily intake of nutrient influence the relationship of
smoking with cytokines level.
Method: This was a cross sectional
study. Study subject consisted of 23
adult, healthy, smoker men.
Ethical clearance was issued by
Commission of Ethics
of Medical and
Public Health Research,
Faculty of Public
Health Diponegoro University.
Smoking variabel was obtained from questions. Level of cytokines examined
consists of IFN-γ, IL-6 and IL-10 was measured
using ELISA (pg/dl).
Nutritional intake was measured
by method of 2x24-hour recall. The difference of level of IFN-γ, IL-6, IL-10
and daily nutrient intake based on smoking degree was analyzed with Mann
Whitney (α 0,05).
Result: The result
showed no difference
in level of
IFN-γ, IL-6 and
IL-10 found between
group of light
and heavy smokers. In
the group of
heavy smokers, daily
nutrient intake was
higher compare to
light smokers. However,
the significant difference only found in vitamin C (p = 0.042).
Conclusion: Immune response, as measured by level of interferon gamma,
interleukin 6 and interleukin 10, do not differ betwen light and heavy smokers
due to micronutrient intake
Penulis: Mohammad Zen
Rahfiludin, Praba Ginandjar
Kode Jurnal: jpkesmasdd130253
