STUDI IN VITRO HUBUNGAN LOGARITMA KOEFISIEN PARTISI DENGAN IKATAN PROTEIN PLASMA DARI ANTI DIABET TURUNAN SULFONIL UREA SEBAGAI BAHAN PEMBELAJARAN MATA KULIAH FARMASI FISIK
Abstract: This paper shows
that oral anti diabetic Sulfonil Ureic derivates (The first generation:
Chlorpropamide, and the second generation : Gliclazide, Glibenclamide &
Glipizide) have logaritmicpartition coefficient value increased. The increased
value in logaritmiccoeficient partition due to modification of chemical
structure of suchcompounds. Such modification caused the polarity property of
such compoundincreases, which in turn, increasing the logaritmic coeficient partition
value.According to this paper that the chemical structure of antidiabet
sulfunil ureicderivates play important role in protein plasm bonding in drug.
This articlecan be used as laboratory practice or studied material on Physical
Pharmacy.
Keyword: InVitro Study, Oral
antidiabetic Sulfunil Ureic derivates, logaritmic partitioncoeficient, protein
plasm bonding
Penulis: Eka Deddy Irawan
Kode Jurnal: jppendidikandd060017
