UJI TOKSISITAS AKUT DARI EKSTRAK ETANOL HERBASEREH (ANDROPOGON CITRATUS D.C ) PADA MENCIT PUTIH SEBAGAI BAHAN PEMBELAJARAN TOKSIKOLOGI
Abstract: Sereh Herb have been
proven to have effect asanalgetic at mice which have been induced by acetic
acid. In order to develop Sereh herb as
fitofarmaka, it requires acute toxicity testfrom sereh herb to know it’s
safety level. Result of this research is expectedto become a studied material
of Toxicology. In acute toxicity test of aethanolextract from sereh herb, mice
divided into 5 groups which consist of 1 negativecontrol group and 4 dose
levels with 2 times interval dose, 200 mg / kg BW, 400mg / kg BW, 800 mg / kg
BW, and 1600 mg / kg BW. Up to maximum volume which maybe given to mice, the
highest dose given to mice did not caused death,therefore the highest dose
expressed as apparent LD50 ( LD0).Thereby, aethanol extract from sereh herb
have LD0 value equal to1600 mg / kg BW. If converted to human being with 50 kg
BW , LD0aethanol extract from sereh herba become 443,6 g / kg BW. Aethanol
extract from sereh herb does not have LD50, this indicate that aethanol extract
from sereh herbdoesn't have potention to make toxic effect, this matter is also
shown by noany clinical symptom at mice. Thereby acute toxicity potention of
Aethanolextract of sereh herb can be classified to relativelynot dangerous
(> 15 g / kgBW ). In conclution, safety levelof Aethanol extract from sereh
herb relatively safe to be consumed by human being.
Kode Jurnal: jppendidikandd050006
