Ekspresi β Catenin dan β4 Integrin pada Karsinoma Sel Basal Agresif dan Nonagresif

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Abstract: Aggressive basal cell carcinoma (BCC) is a high risk type of BCC which frequently locally aggressive and has been associated withgreater subclinical depth of extension and a greater rate of local recurrence in BCC with aggressive histopathologic variants. Recently,the role of molecular biology in predicting aggressiveness of BCC has not been clear. The purpose of this study was to determine theexpression of β catenin and β4 integrin in aggressiveness of BCC, to analyze the expression of β catenin and β4 integrin which aregreater in aggressive BCC than non aggressive BCC. This study was an observational with cross sectional study from 58 primaryBCC patients visited skin surgery/Tumor division Outpatient clinic M Hoesin General Hospital Palembang during period Januari2008–December 2009 was involved. Characteristic primary BCC patient results were recorded. Skin biopsy from primary BCC lesionwere taken and Histopathological examination for detection BCC subtype and Immunohistochemistry test for detection of β cateninand β4 integrin was performed. The level of β catenin and β4 integrin was measured quantitatively. Statistically data were analyzedby using the chi-square, independent sample t test, and multiple logistic regression. The results of this study showed in primaryBCC, there was a signifi cant correlation between expression of β catenin and β4 integrin in aggressive and non aggressive of BCC(p < 0.05), the expression of β catenin (t = –5006, p = 0,00) and β4 integrin (t = –3.714, p = 0.00) was signifi cant greater in aggressivethan non aggressive of BCC, there was signifi cant correlation between expression of β catenin and β4 integrin in aggressiveness ofBCC (β catenin p ≤ 0.002, OR = 1.154; β4 integrin p ≤ 0.004, OR = 1,067), which means the infl uence of β catenin a strong signifi cant1,154 time and β4 integrin a strong signifi cant 1,067 time in aggressiveness of BCC. The expression of β catenin and β4 integrin weresignifi cantly greater in aggressive than non aggressive BCC, and there were signifi cant correlation of β catenin and β4 integrin inaggressiveness of BCC with the type of histopathology of BCC based on growth pattern.
Keyword: β catenin, β4 integrin
Penulis: Yulia Farida Yahya, Saut Sahat Pohan, Soetjipto, I Ketut Sudiana
Kode Jurnal: jpbiologidd120049

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Jp Biologi dd 2012