Ekspresi Extracellular Signal Regulated Kinase (ERK1/2), Reseptor Estrogen (ER) a, dan Insulin Like Growth Factor I (IGF-IR) pada Osteoblas dalam Memengaruhi Kepadatan Tulang Tikus Putih (Rattus Norvegicus) Betina Usia Muda Pasca-Latihan Fisik
Abstract: It is known that
exercise training can increase bone density both for male and female on human
and animals. The fact shows that increase bone density mechanism by exercise
training up to know is not yet clear. Exercise training in the young is very
important because one of the main cause factors of osteoporosis is peak reach
of bone density that is not optimal in the young. It can cause bone strength
decreasing. This research was aimed to know the effect of exercise training on
moderate intensity on ERα, ERK1/2, and IGF-IR expression and it’s role in
influencing bone density. This research was The Randomized Posttest only
Control Group Design. The experimental unit in this research was white rat
strain wistar, female in the age of 4 moths, and total number were fourteen.
Independent variables of this research was exercise training on moderate
intensity, and dependent variables were ERα, ERK1/2, and IGF-IR expression and
bone density. ERα, ERK1/2, and IGF-IR expression was measured by using
immunobloting methode, while bone density was measured by using ultra-sound DBM
1200. The data analysis used was MANOVA and Pearson correlations. Base on
MANOVA analysis showed that there were increasing of ERα, ERK1/2, and IGF-IR
expression and bone density together on exercise training (p = 0.00 < α =
0.05). Based on Pearson correlation analysis showed that increasing ERα,
ERK1/2, and IGF-IR give contribution in increasing bone density r = 0.692 for
ERα, r = 0.711 for ERK1/2, and r = 0.608 for IGF-IR (αααααααααααααααααααααααα=
0.05). Futhermore a strong correlation was found between ERα and IGF-IR r =
0.965 and EKR1/2 r = 0.985 also between IGF-IR and ERK1/2 r = 0.914
(ααααααααααααααααα= 0,05). ..............There fore this study concluded that
exercise training be able to increase bone density through ERK1/2-ERα-IGF-IR
pathway.
Penulis: Nurul Mahmudati, Martin
Setiabudi, Indri Safitri Mukono, I.B. Tjakra Wibawa Manuaba
Kode Jurnal: jpbiologidd110040
