Mekanisme dan Aktivitas Antimalaria dari Senyawa Flavonoid yang Diisolasi dari Cempedak (Artocarpus Champeden)

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Abstract: This study was aimed to monitor Flavonoid Compound activity and mechanism as antimalaria that isolated from A. Champeden. Two new prenylated flavones, 5,7,2′,5′-tetrahydroxy-4′-methoxi-3-prenylflavone and 5,7,2′,4′-tetrahydroxy-8-prenylfuranodihydrobenzoxanthone, named after artocarpones A and B respectively, have been isolated from the stembark of Artocarpus champeden, together with six known isoprenylated flavonoids: artonin A, cycloheterophyllin, heterophyllin, artoindonesianin R, heteroflavanone C, artoindonesianin A-2, and one flavanone artoindonesianin E. Their structures were determined on the basis of spectroscopic analysis. The isolated compounds were all tested for their antimalarial activity against the growth of Plasmodium falciparum 3D7 in vitro and the results indicated that all but one compound, artoindonesianin E (IC50 = 75.76 μM), inhibited the parasite growth significantly. The highest antimalarial activity was shown by heteroflavanone C (IC50 = 0.001 μM). An attempt to determine its mechanism of action by using sorbitol-induced hemolysis inhibitory assay revealed that artoindonesianin R, artocarpone A and artoindonesianin A-2 showed hemolysis inhibition over 60% and, therefore, identified as inhibitor of the NPP of the infected erythrocyte. The results indicated that flavonoid compounds from this A. champeden exhibited potent antimalarial activity through either inhibition of the parasite inducing new permeation pathway or other yet unidentified mechanism. Therefore, the compounds are potential to be developed as new antimalarial drugs, through phytopharmaceutical product of its stembark or synthesized products of the compounds.
Keyword: Artocarpus champeden stembark
Penulis: A ty Widyawaruyanti, Noer Cholis Zaini, Syafruddin
Kode Jurnal: jpbiologidd110045

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Jp Biologi dd 2011