PENGARUH TRITERPEN TOTAL PEGAGAN (Centella asiatica (L) Urban) TERHADAP FUNGSI KOGNITIF BELAJAR DAN MENGINGAT PADA MENCIT JANTAN ALBINO (Mus musculus) YANG DIHAMBAT DENGAN SKOPOLAMIN

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ABSTRACT: Pegagan  (Centella  asiatica  (L)  Urban)  has  been  described  to  posses  CNS  effects such as  improving cognitive  function,  learning and  memory. The aim of the research was to  evaluate  the effects of total triterpen’s pegagan extract on cognitive functions as the learning  and  memory  performance  in  male  albino  mice  (Mus  musculus)  inhibited  by scopolamine. The research design was Complete Randomized Design (RAL) - factorial on thirty  six  mice  divided  into  4  groups.  One  control  group  received  only  aquabidest (negative control). Three treatment groups received total triterpen 16 mg/kg BW, 32 mg/kg BW  orally  and  piracetam  500  mg/kg  BW  by  intra  peritoneally  (positive  control)  for  21 days. Data indicating learning and memory process of all subjects were obtained from one-trial passive avoidance test. Data were analyzed by two way ANOVA and BNT (p<0,05). Result showed that total triterpen 32  mg/kg BW  had  significantly prolonged the retention time  compared  to  control  group  indicating  improvement  in  cognitive  function  (505,03 second  vs -18,53 second) (p<0,05) and  it was  not significantly different to piracetam 500 mg/kg BW group (505,03 second vs 522,48 second) (p>0,05). In conclusion, total triterpen from pegagan (Centella asiatica (L) Urban) improved learning ability and memory of male albino mice (Mus musculus) even though, it was inhibited by scopolamine.  
Key words: Pegagan, cognitive function, passive avoidance test
Penulis: Herlina
Kode Jurnal: jpbiologidd100033

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Jp Biologi dd 2010