PENGARUH TRITERPEN TOTAL PEGAGAN (Centella asiatica (L) Urban) TERHADAP FUNGSI KOGNITIF BELAJAR DAN MENGINGAT PADA MENCIT JANTAN ALBINO (Mus musculus) YANG DIHAMBAT DENGAN SKOPOLAMIN
ABSTRACT: Pegagan (Centella
asiatica (L) Urban)
has been described
to posses CNS
effects such as improving
cognitive function, learning and
memory. The aim of the research was to
evaluate the effects of total
triterpen’s pegagan extract on cognitive functions as the learning and
memory performance in
male albino mice
(Mus musculus) inhibited
by scopolamine. The research design was Complete Randomized Design (RAL)
- factorial on thirty six mice
divided into 4
groups. One control
group received only
aquabidest (negative control). Three treatment groups received total
triterpen 16 mg/kg BW, 32 mg/kg BW
orally and piracetam
500 mg/kg BW
by intra peritoneally
(positive control) for 21
days. Data indicating learning and memory process of all subjects were obtained
from one-trial passive avoidance test. Data were analyzed by two way ANOVA and
BNT (p<0,05). Result showed that total triterpen 32 mg/kg BW
had significantly prolonged the
retention time compared to
control group indicating
improvement in cognitive
function (505,03 second vs -18,53 second) (p<0,05) and it was
not significantly different to piracetam 500 mg/kg BW group (505,03
second vs 522,48 second) (p>0,05). In conclusion, total triterpen from
pegagan (Centella asiatica (L) Urban) improved learning ability and memory of
male albino mice (Mus musculus) even though, it was inhibited by scopolamine.
Penulis: Herlina
Kode Jurnal: jpbiologidd100033
