Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC)
Abstract: Formulation of
chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda
citrifolia L fruits and investigation of the activity towards liver damage
induced by tuberculosis drugs has been performed. The rats were devide into six
groups. The normal control without any treatment, negatif control were given
INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol,
and the treatment group were given INH-RIF with chewable tablets of papaya
extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula
with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The
measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and
28th day. The study showed that the group that given chewable tablets of
combination of papaya extract 120mg/200g and morinda extract 20mg/200g can
prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%)
and 19,90 (PVP1%), compared to the negative control of 41.78% as well as
reducing the value of ALT, AST and bilirubin. The tablet formula that can be
received on the best of taste and most effective as hepatoprotektor is the
chewable tablet with PVP 3%.
Penulis: Titik Sunarni, Rini
Prastiwi, Ilham Kuncahyo, . Mardiyono, Yudi Rinanto
Kode Jurnal: jpfarmasidd130037
