Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik
Abstract: Nanopraticles can be
prepared by several methods and the ionic gelation method is the easiest one.
Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and
antihypertension therapy. Nevertheless, bioavailability of orally administered
verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride
was prepared as nanoparticles dosage form to increase its bioavailability. The purpose of the present
study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate
to obtain the best nanoparticles formulation. Nanoparticles were obtained from
four different methods (formula A, B, C and D). Particle size distribution,
zeta potential, entrapment efficiency, morphology, and fourier transform infra
red spectrum of each nanoparticles formula were characterized. The chosen
formula was formula D which has 62.8 nm of size, 59.15% of entrapment
efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic
interaction was confirmed by FT-IR spectrum. The result showed that
chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride
nanoparticles by ionic gelation method.
Penulis: Raditya Iswandana,
Effionora Anwar, Mahdi Jufri
Kode Jurnal: jpfarmasidd130035
