Hubungan Kadar Pb dalam Darah dengan Kejadian Hipotiroidisme pada Wanita Usia Subur di Perkampungan Usaha Kecil dan Menengah Desa Pesarean Kabupaten Tegal
Abstract: Hypothyroidism on
women at childbearing age (WCA) can cause reproduction disorder, i.e.
infertility,spontaneous abortion, impaired growth and development of foetus,
placental abruption, and preterm delivery.Exposure tolead(Pb) at low lever contunuely
for a long time willresult thyroid dysfunction. This research aimedtoprove that
lead exposure is a risk factor for thyroid dysfunction among WCA in metal
industrial of Pesarean inTegal districtMethods: Cross-sectional studyused32 subjects
researchatmetal industrial PesareanDistrictof Tegal. Pblevelsinthe bloodwas
used asbiomakerofPbexposure. Thyroid dysfunction was determined based on the
result ofTSH(Thyroid Stimulating Hormone). Confounding variables were also
measured. These variables were age,length of stay, participation in hormonal
contraception, iodine intake, pesticide exposure, exposure to cigarettesmoke,
and employment history. Data would be analyzed using chi-square test at 0,05
level of significancy.Result: The prevalence of hypothyroidism among WCA was 25
%. Lead exposure was a risk factor for hypothyroidism(95 % CI, PR=
11,667(1,628- 83,597); and p-value = 0,002. The higher the degree of exposure,
the greater therisk of having thyroid dysfunction. Based on data and the theory
analysis, the pathogenesis of hypothyroidismwas suspected through the
disruption of TPO function, D1 enzyme inhibition and D3 enzyme
activation.Conclusion: Lead exposure was a risk factor for thyroid dysfunction
among WCA in metal industrial township.
Penulis: Novi Hidayati,
Suhartono, Nurjazuli
Kode Jurnal: jpkesmasdd130451
