Hubungan Kadar Pb dalam Darah dengan Kejadian Gangguan Fungsi Hati pada Pekerja Peleburan Timah Hitam di Kabupaten Tegal
Abstract: Lead (Pb) is a toxic
material which easily accumulated in human organs and can cause health
problems.Pb in the blood can cause damage to a variety of human organs
including the liver. Results of preliminary studies inSmall Industry Village
(PIK) Kebasen Tegal obtained that the air lead concentratios exceed the
required standard,lead concentrations in the blood and parameters of liver
function (AST, ALT and Gamma GT) on several workers wellbeyond normal
limits.Methods : Cross-sectional study on 55 subjects research at Small
Industry Village Kebasen Talang District Tegalregency. Pb levels in the blood
as biomarker of Pb exposure on levels of ALT, AST and Gamma GT as a parameter
formeasuring the physiology of Liver function. Data were collected through
observation, interviews and laboratorytests. Univariate analysis, bivariate
analysis by Chi-square, then followed by multivariate logistic
regression.Result : Kendall Tau test showed significant association between
blood lead level with the level of AST (p = 0.000),ALT (p = 0.025) and Gamma GT
(0.001). Result of Chi-square test showed significant association between blood
leadlevel with liver dysfunction (p = 0.002), prevalence ratio (PR) with 95% CI
= 1.783 (1.360 to 2.337).Conclusion : There is a significant association
between blood lead level and liver dysfunction on lead exposedworkers at small
industries villages Kebasen district Tegal.
Penulis: Fidiyatun, Onny
Setiani, Suhartono
Kode Jurnal: jpkesmasdd130457
