Hubungan Kadar Timah Hitam dalam Darah dengan Jumlah Lekosit, Trombosit, dan Aktifitas Superoxide Dismutase (SOD) pada Pekerja Timah Hitam di Kabupaten Tegal
ABSTRACT: Air pollution is a
serious matter which can damage environments also human health. In Indonesia,Lead
(Pb) has huge potential to harm and to damage environments on industrial area.
The inserted of lead into human bodies
especially by inhaling of lead´s dust through respiratory tract, most of
the Lead will bounded in red blood cells, than the rest of it will be
accumalated in bone marrow and soft tissues and would bring impact of disturbances
of haematopoesis, cardiovascular, renal, nervous, gastrointestinal, and
reproductive systems and also carcinogenic. This study aimed to find out the
degree of exposure to Lead and its effect haematologic system mainly leukocyte
count, platelet count and activity of Superoxide Dismutase (SOD).
Methods: It was an observational research using cross sectional design.
The subject of research was 41 workers. Blod Lead Level (BLL)l as independent
variable was examined using AAS. Dependen variable of this research was blood
profile consist of Lekosit, Trombosit, dan Activity of Superoxide Dismutase
(SOD). Data would be analyzed using Kendall Tau correlation.
Result: Blood lead level (BLL) wasmeasured using AAS examination of 41
workers found on average 27.069 µg/ dl,
Permmision Exposure Limit 0.6 µg/dl –
108.3 µg/dl exceed the limit of Centre for Disease Controle and Prevention
(CDC=10 µg/dl). Examination of leukocyte count results p 0.034 (p<0.05),
average 7256,9/mm³, range 3800–12700/mm³, while
platelet count p 0.857 (p>0.05), average 277634.2/mm³, range
143000–391000/ mm³, and SOD activity p 0.220 (p>0.05), average 82.304 U/ml,
range 72.11-95.92 U/ml still normal.
Conclusion: The level of BLL on
workers had been over treshhold limit value (TLV)and It had significantly correlation
with the level of leucocite (p-value < 0.05).
Recommendation: Medical and preventive action are needed to restore and
prevented worsening effect on health by administering medication, routin
check-up, natural chelating agent and supplement and healthly environment programs
applied.
Key words: Blood Lead Level
(BLL), leukocyte count, platelet count, Superoxide Dismutase (SOD) activity
Penulis: Lily Gunawan, Onny
Setiani, Suhartono
Kode Jurnal: jpkesmasdd130449
