Koproses Karagenan-Pragelatinasi Pati Singkong Propionat sebagai Eksipien Sediaan Tablet Mengapung
Abstract: The aim of this
study was to prepare floating tablet dosage forms using coprocessed of kappa
and iota carrageenan and pregelatinized cassava starch propionate (PPSP) as
excipients. In this study, tablets were made by wet granulation method and
using famotidine as a model drug. Several formulations of floating tablets were
prepared using varying composition of the excipients coprossed carragenan with
a certain ratio. The swelling and bupyancy of the floating tablets were
evaluated. Furthermore, the drug release from the floating tablets were studied
and analyzed using several models of kinetic equations. The result showed that
formula A with excipients coprocessed carragenan (1:1) as much as 60% with 10%
HPMC produce the best formula with floating lag time 11.42±1.53 minutes and
total floating time for 22 hours. The formula also revealed a profile of
controlled drug release and approached to Higuchi kinetics model and the non
Fickian diffusion mechanism.
Penulis: Junaedi, Iskandarsyah,
Effionora Anwar
Kode Jurnal: jpfarmasidd130033
