MIKROENKAPSULASI METFORMIN HIDROKLORIDA DENGAN PENYALUT ETILSELLULOSA MENGGUNAKAN METODA PENGUAPAN PELARUT
Abstrak: Metformin
hydrochloride is a biguanide class of oral antidiabetic drugs that have a
half-life 1.5 to 3 hours, and it administration was repeated. In order to
support the treatment of diabetic disease, metformin hydrochloride was made
into microcapsules as a maintenance dose using solvent evaporation method using
ethyl cellulose as a coated. The
comparison between metformin hydrochloride and ethyl cellulose were 1: 0.75; 1:
1 and 1: 1.25. Microencapsulation evaluated by microscopic photograph, assay
and dissolution test. At the microscopic picture shows metformin hydrochloride
veiled by a layer of ethyl cellulose. The amount of metformin hydrochloride in
F1 is 20.73%, 15.40% at FII and FIII is 10.11%. The biggest drug release
inhibiton was achieved in formula 3 (1; 1.25) with dissolution efficiency was
0.170.
Penulis: Deni Noviza, Tita
Harliana, Ade Arinia Rasyad
Kode Jurnal: jpfarmasidd130026
