PENGARUH KOMBINASI SURFAKTAN NATRIUM LAURYL SULFAT DAN BENZALKONIUM KLORIDA TERHADAP KELARUTAN IBUPROFEN
Abstrak: A study on the
influence of sodium lauryl sulfate and benzalkonium chloride combination on the
solubility of ibuprofen has been done. The solubility of ibuprofen with sodium
lauryl sulfate, benzalkonium chloride and it’s combination was determined by
surface tension method with Du Nouy Tensiometer and by refractive index method
with Refractometer ABBE. The solubility was determined at surfactant
concentration above the CMC value. Results showed that formula 4 gave the
highest solubility of ibuprofen (96,25 %). Combination of the surfactants
caused precipitation.
Penulis: Syofyan, Tuti Agustia
Safari, Rieke Azhar
Kode Jurnal: jpfarmasidd130025
