Pengaruh Pemberian Ekstrak Etanol Umbi Mahakaan terhadap Waktu Perdarahan dan Pembekuan serta Jumlah Trombosit Darah Mencit Putih Betina
Abstract: The effect of
aethanolic extract of mahakaan's (Gynura pseudochina (L) DC tuber on shortening
bleeding and coagulation time and trombocytes cell of the white female mice has
been studied. The overal doses used were 30,100 and 300 mg/kg BW. The effect
was observed on 1st, 7th, 14th and 21st days by using the modified cutting tail
method, slide method and using hemositometer. As a comparator used vitamin K
with dose of 0,026 mg/20g BW was given. The result indicated that the extract
has ability to shorten bleeding and coagulation time at all doses, and the dose
of 300 mg/kg BW showed a stronger effect on shortening bleeding time compared
to vitamin K 0,026 mg/20g BW (p<0,01). The doses of 100 and 300 mg/BW showed
a stronger effect on shortening coagulation time. The thrombocytes was not
influenced by the all doses, and neither was the lenght of the administration
(p>0,01).
Penulis: Surya Dharma,
Dachriyanus, Zikra Sartika
Kode Jurnal: jpfarmasidd130030
