NUTRIGENOMIC STUDY: Igf-1 INHIBITION IN ADIPOGENESIS OF VISCERAL ADIPOSE TISSUE OF RAT USING RAMBUTAN PEEL EXTRACT

Abstract: This  study  observes  the  inhibition  of  rambutan  peel extract to  rat visceral adipose tissue adipogenesis by observing the expression  of  igf-1.  Experiment  stages  consist  of  rambutan  peel extraction, rat treatment, visceral adipose tissue protein isolation and separation,  and  western  blot.  Male  wistar  rats  were  divided  into normal and obese rats. The treatments consist of control, ellagic acid, placebo,  and  extract  at  5,  10,  15,  and  20  mg/kg  body  weight. Decreasing body weight gain observed in obese rats with similar food intake  (P>0,05).  Effective  dose  observed  at  10mg/kg,  whilst  at  20 mg/kg  showed  increasing  body  weight.  Protein  profile  shows different band numbers and intensity between groups and treatments. Igf-1 expression is bound to Igfbp-1 at 36,7 kDa. Anti-obesity effect observed  at  10  mg/kg  extract  in  obese  rats.  Interestingly,  igf-1 expression is lower at 20mg/kg group. This result suggest that obesity inhibition does not go through IR family tyrosin kinase.

Index Terms: Adipogenesis, rambutan peel extract, Igf-1, obesity

Author: Rizky Nurdiansyah, Sri Rahayu Lestari and Fatchiyah

Journal Code: jpbiologigg130006

Artikel Terkait :

Jp Biologi gg 2013

• THE DYNAMICS OF PANDANUS ILLUSTRATIONS FROM A HISTORICAL PERSPECTIVE
• A NEW SPECIES OF BEGONIA (BEGONIACEAE) FROM SOUTH SULAWESI, INDONESIA
• A NEW SPECIES OF FREYCINETIA GAUDICH. (PANDANACEAE; FREYCINETOIDEAE) FROM TIDORE ISLAND, MOLUCCAS, INDONESIA
• PANDAN (PANDANACEAE) IN FLORES ISLAND, EAST NUSA TENGGARA, INDONESIA: AN ECONOMIC-BOTANICAL STUDY
• A REVISION OF RHYNCHOGLOSSUM (GESNERIACEAE) IN MALESIA
• THE UNIQUE CHARACTERS AND HABITAT OF FREYCINETIA (PANDANACEAE) WITH SEVEN NEW SPECIES IN TIMIKA, WEST PAPUA, INDONESIA
• FLORISTIC STUDY OF WEST SUMBAWA, INDONESIA
• LIGHT INTENSITY AND THE SPREAD OF Cestrum aurantiacum Lindl. IN A SECONDARY MOUNTAINOUS REMNANT FOREST
• The Diversity of Tropical Orchids of South Papua
• KINETICS OF GASEOUS TOLUENE ADSORPTION ON CANDLENUT SHELL ACTIVATED CARBON
• The Predicted Distribution of Javan Munia (Lonchura leucogastroides) in Indonesia based of Behavior Analysis in Kalibaru, Banyuwangi, East Java
• MOLECULAR CHARACTERISATION of Polymesoda erosa (Solander, 1786) INHABIT TWO DIFFERENT HABITATS
• ISOLATION OF COMMON CARP b-ACTIN PROMOTER
• K-CROSSING CRITICAL ALMOST PLANAR GRAPHS
• THE DIVERSITY OF EPIPHYTIC FERN ON THE OIL PALM TREE (Elaeis guineensis Jacq.) IN PEKANBARU, RIAU KEANEKARAGAMAN JENIS PAKU EPIFIT YANG TUMBUH PADA BATANG KELAPA SAWIT (Elaeis guineensis Jacq.) DI PEKANBARU, RIAU