Comparison of pulmonary functions of thalassemic and of healthy children

ABSTRACT: Objectives The aim of this study was to compare some pulmo-nary functions of thalassemic patients and those of normal chil-dren. Factors correlated with lung dysfunction were assessed. Methods This cross-sectional study compared some pulmonary functions of thalassemic patients with those of healthy children.The study was performed in the Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Pre- and post-trans-fusion hemoglobin levels of the thalassemic subjects were deter-mined. Other data such as chelation therapy and serum ferritin levels were also obtained. Both thalassemic and control subjects underwent routine physical examinations and lung function tests using an electronic spirometer. Spirometry  was repeated three times for each subject, and only the best result was recorded. Results Sixty-three thalassemic patients were enrolled, consist-ing of 32 male and 31 female subjects. Healthy subjects consisted of 31 males and 31 females. Most thalassemic patients (46/63) were found to have lung function abnormalities. This was signifi-cantly different from control subjects, of whom most (39/62) had normal lung function. Restrictive lung function abnormality was the most common (42/63) observation documented. Serum ferritin lev-els were obtained from 28 male and 29 female thalassemic sub-jects. There was no correlation between percentage from predicted forced vital capacity and serum ferritin levels, whether in male (r=0.191; P=0.967) or female (r =-0.076, P=0.695) thalassemic subjects. Conclusion  Thalassemic patients have significantly lower lung function than healthy children. More thalassemic patients had lung function abnormalities compared to healthy children. Restrictive dysfunction was the most common finding in the thalassemic group. No correlation was found between lung function and serum ferritin levels.

Keywords: pulmonary function, thalassemia, spirom-etry, serum ferritin level, restrictive lung dysfunction

Author: Mardjanis Said, MD; Sudigdo Sastroasmoro, MD, PhD; Djajadiman Gatot, MD; Bambang Supriyatno, MD; Yovita Ananta, MD

Journal Code: jpkedokterangg050001

Artikel Terkait :

Jp Kedokteran gg 2005

• Treatment of taeniasis and cysticercosis with praziquantel and albendazole
• The benefits of progesterone therapy in imminent abortion
• PM10 as Predictor of Ventilation Efficiency of Houses in Relation to Health Effect
• Fatty acids intake among diverse ethnic groups in Indonesia
• The effects of balanced low calorie diet on body composition and serum leptin of obese women
• QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction
• Endoscopical appearances of nonsteroidal anti inflammatory drug (NSAID)- enteropathy
• Role of general practitioner in the management of acute myocardial infarction
• Genotyping of hepatitis B virus from dried and stored serum on filter paper
• Development of bioassay for pathogenecity testing of Ureaplasma urealyticum as part of host-pathogen communication
• Detection of GAD65 autoantibodies of type-1 diabetes using anti-GAD65-abs reagent produced from bovine brain tissue
• The use of ceftriaxone impregnated beads in the management of chronic osteomyelitis
• The correlation between total lymphocyte count and the number of candida colony from the oral cavity in HIV/AIDS patients
• Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment
• Left ventricular diastolic dysfunction in type 2 diabetes mellitus patient without cardiovascular disease: the association with microalbuminuria
• Hormonal contraception as a risk factor for obesity
• Effect of irrigating fluid temperature on core body temperature during transurethral resection of the prostate
• T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases
• Intracranial germ cell tumour with extra cranial extension in a four month old infant – a case report
• Drospirinone: new generation of progestogen
• Implementation of 25-well culture plates for M. tuberculosis drug susceptibility testing in Indonesia
• Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis
• Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities)
• Age, duration of work, noise and vibration in inducing hearing and balance impairments
• Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor