Diagnostic test of endometrial cytobrush in cases of perimenopausal and postmenopausal hemorrhage
Abstract: Perimenopausal
menopausal hemorrhage can be due to by a variety of causative factors. One of
its dangerous causes is atypical hyperplasia and endometrial carcinoma. There
are a number of risk factors for the occurrence of endometrial carcinoma. The
group that has this risk belongs to high-risk group. In this high-risk group,
it is necessary to have a method to identify the changes in endometrial
abnormality. One of the alternatives is the examination of endometrial
cytology. The objective of this study was to evaluate the sensitivity,
specificity and correlation test between endometrial cytology and endometrial
histology. This study was a diagnostic test of cytological examination of the
endometrium as compared with endometrial histology. Endometrial cytology was
performed with a modification of cytubrush and IUD shell. Specimen was
dissolved into the centrifuged NaCl, and its deposits were then processed for
cytological examination with Papanicolaou and Giemsa staining. After the taking
of cytology, the process was continued with curettage of the endometrium, and
the specimens were processed for cytological examination. Both of them were
examined by anatomic pathologist. Statistical analysis used diagnostic test
using histological examination of curetage specimens as gold standard. During
the period of study 45 study samples were collected, among which 12 (26.66%)
were endometrial adenocarcinoma, 6 (13.33%) with atypical hyperplasia, 11
(24.44%) with non-atypical hyperplasia, 15 (33.33%) were samples without
abnormality, and one sample with endometritis. Actual correlation value was
57.8%, correlation because of possibility 3.38%, and correlation not because of
possibility 54.42%, potential correlation not because of possibility 96.62%,
and Kappa value 0.56. It was concluded that cytological examination of the
endometriurn with cytobrush could be employed as a screening method in the
abnormalities of endometrial thickness, with sensitivity of 62.5% and
specificity of 62.2%.
Author: Andrijono, Gunawan D.
Prayitno, Chairil Hamdani
Journal Code: jpkedokterangg050121
Artikel Terkait :
Jp Kedokteran gg 2005
- Treatment of taeniasis and cysticercosis with praziquantel and albendazole
- The benefits of progesterone therapy in imminent abortion
- PM10 as Predictor of Ventilation Efficiency of Houses in Relation to Health Effect
- Fatty acids intake among diverse ethnic groups in Indonesia
- The effects of balanced low calorie diet on body composition and serum leptin of obese women
- QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction
- Endoscopical appearances of nonsteroidal anti inflammatory drug (NSAID)- enteropathy
- Role of general practitioner in the management of acute myocardial infarction
- Genotyping of hepatitis B virus from dried and stored serum on filter paper
- Development of bioassay for pathogenecity testing of Ureaplasma urealyticum as part of host-pathogen communication
- Detection of GAD65 autoantibodies of type-1 diabetes using anti-GAD65-abs reagent produced from bovine brain tissue
- The use of ceftriaxone impregnated beads in the management of chronic osteomyelitis
- The correlation between total lymphocyte count and the number of candida colony from the oral cavity in HIV/AIDS patients
- Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment
- Left ventricular diastolic dysfunction in type 2 diabetes mellitus patient without cardiovascular disease: the association with microalbuminuria
- Hormonal contraception as a risk factor for obesity
- Effect of irrigating fluid temperature on core body temperature during transurethral resection of the prostate
- T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases
- Intracranial germ cell tumour with extra cranial extension in a four month old infant – a case report
- Drospirinone: new generation of progestogen
- Implementation of 25-well culture plates for M. tuberculosis drug susceptibility testing in Indonesia
- Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis
- Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities)
- Age, duration of work, noise and vibration in inducing hearing and balance impairments
- Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor