GASTROPROTECTIVE EFFECT OF CURCUMINE ON ETHANOL-INDUCED GASTRIC MUCOSAL LESIONS IN RATS
ABSTRACT: This study was
conducted to investigate the protective effect of curcumine (50 mg/kg/day; 100
mg/kg/day and 200 mg/kg/day orally for 15 days) in ethanol-induced gastric
mucosal lesions in male Wistar rats. Ulceration was induced in rats by
administering 50 % ethanol orally. On day 16, the stomach was examined for
ulcer by the severity of hemorrhagic erosions in acid secreting glandular
mucosa. Total acid and peptic activity were determined in gastric juice using
hemoglobin as substrate. Reduce glutathione (GSH) and glutathione peroxidase
(GPX) were also estimated from gastric mucosa. Pretreatment with curcumine 100
mg/kg/day and 200 mg/kg/day for 15 days significantly reduced the incidence and
severity of gastric erosions induced by ethanol. Curcumine treatment also
favorably altered changes in volume and peptic activity of gastric juice in
ethanol-treated animals. Furthermore, the levels of GSH and GPX were significantly
decreased after treatment with ethanol, and this decrease was prevented by
curcumine. The study provides evidence for possible involvement of glutathione
in the curcumine-mediated gastroprotection against ethanol-induced ulceration.
Author: Sri Agus Sudjarwo
Journal Code: jpkedokterangg050015
