Hormonal contraception as a risk factor for obesity
Abstract: Hormonal
contraception is related to change in the metabolism of some nutrients that may
lead to an increase in body weight. The aims of this study is to assess the
risk of obesity in hormonal contraceptive users in the District of Kulon Progo,
Jogjakarta, Indonesia. A cross sectional study was used to determine the
prevalence of obesity among users of contraception. A systematic cluster random
sampling, using villages as clusters, was used to choose 647 users of
contraception in Kulon Progo. A hundred
and two obese cases and 102 control, matched-for-age and socioeconomic status,
controls were included in the case control study used to evaluate the risk of
obesity among users of hormonal contraception. The prevalence of obesity among
users of contraception in Kulon Progo was 15.9%. Users of hormonal
contraception has a increased risk for obesity, OR: 9.4 (95% CI: 1.1 – 81.5).
Users of combination pills faced the highest risk, followed by users of injected
progesterone depot, while the risk in implant users was the same as that in
users of non-hormonal contraception. The risk of obesity was significantly
higher after 7 years of hormonal contraception use. The risk of obesity was
neither related to energy intake nor expenditure. The increased risk of obesity
in users of hormonal contraception was still significant after controlling for
age, parity, initial weight, socioeconomic status, energy intake and
expenditure, and parental obesity. We conclude that the risk of obesity is
higher in users of hormonal contraception compared to the non-hormonal ones.
Users of combination pills face the highest risk of obesity.
Author: Sri Sugiharti, Hamam
Hadi, Madarina Julia
Journal Code: jpkedokterangg050131
