IMMUNOLOGICAL ASPECT ON BONE CELLS
ABSTRACT: Immunological aspect
on bone cells is closely connected with the existence of estrogen. There are so
many immune factors depend on estrogen. Functional interdependence between
immune and bone systems is reflected in a number of regulatory molecules acting
on the cells of both systems and common precursors for bone and immune cells.
Therefore, the disturbances of the immune system may affect bone metabolism,
and vice versa. This review addresses the roles of two major immune cell
populations, T and B lymphocytes, in the regulation of bone metabolism.
Experimental models and human diseases demonstrated that T lymphocytes may
produce many bone cell regulatory cytokines, including two essential
stimulators of osteoclastogenesis: receptor for activation of nuclear factor
kappa b (NF-κB) (RANK) ligand (RANKL) and macrophage colony-stimulating factor
(M-CSF). This journal will reveal some of estrogen roles on bone immunology
system that can affect bone metabolism.
Author: Viskasari Pintoko
Kalanjati
Journal Code: jpkedokterangg050049
