Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor
Abstract: There are several
methods for diagnosing ovarian carcinoma, such as gynecological examination,
ultrasonographic examination, and tumor marker examination. However, all these
combinations have not yielded high specificity antl sensitivity results. For
this reason, it is necessary to perform other examinations to enhance both
specificity and sensitivity, and one of them which is of interest to be studied
is cytological examination of uterine cavity. By cytological examination of
uterine cavity, it is hope that malignant cells originating from ovarian
malignant tumor can be found. Discovery of ovarian malignant cells is possible
because of peristaltic mechanism in the fallopian tube and negative pressure
from uterine cavity, that makes possible the transportation of ovarian
malignant cells into uterine cavity through the tube. The objective of this
study is to understand the sensitiviry and specificity of cytological examination
of uterine cavity in detecting ovarian malignancy. This stucty was a diagnostic
test with histological examination as the gold standard, to understand
sensitivity, specificity, positive prediction value, and negative prediction
value of cytological examination of uterine cavity. A total of 30 cases were
included in the study. A nurnber of factors enhanced positive results in
cytology of uterine cavity. Those factors were stage and ascites. The more
advanced the stage, the greater the positive results, and the presence of
ascites increased positive results. On diagnostic test, sensitivity of uterine
cavity cytology was 48%, specificity 60, positive predictive value 85.7%, and
negative predictive value 18.8% respectively. In conclusion, cytological examination
of uterine cavity could be used as one of the methods in assistirtg the
diagnosis of ovarian carcinoma.
Author: Andrijono, Isrin
Ilyas, Chairil Hamdani
Journal Code: jpkedokterangg050122

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