RISK FACTORS OF SYMPTOMATIC AND ASYMPTOMATIC OSTEOARTHRITIS OF THE KNEE

ABSTRACT: To determine the risk factors of osteoarthritis (OA) of the knee.  Design:  Unmatched case-control study. Setting: Dr.Soetomo Hospital Surabaya, a tertiary government hospital.  Methods:  239 cases of symptomatic - radiographic (Kellgren-Lawrence I or more) OA of the knee taken from rheumatology out-patient clinic, and 175 cases of asymptomatic - radiographic (Kellgren-Lawrence I or more) OA of the knee and 279 controls without radiographic (Kellgren-Lawrence 0) OA of the knee taken from General Internal Medicine Out-patient Clinic at the same hospital were analyzed through multiple logistic regressions. Group compared: A. Symptomatic cases compared to controls. B. Asymptomatic cases compared to controls. C. Their women subsets compared to that of controls.  Results:  1) Symptomatic cases compared to controls: age > 50 (aOR:1.86, 95% CI:1.78-2.82), being female (aOR: 2.08,95% CI: 1.35-3.50), BMI > 25 units (aOR: 3.28,95% CI: 2.20-4.89), elementary education (aOR:0.29, 95% CI:0.14-0.61), genu valgus (aOR: 4.07, 95% CI:2.43-7.93). 2) Women subset of symptomatic cases compared to that of controls: age > 50 (aOR:9.34,95% CI:4.77-18.24), BMI > 25 units (aOR: 5.27,95% CI:2.85-9.73), genu valgus (aOR: 13.64, 95% CI:4.58-41.44). 3) Asymptomatic cases compared to controls: age > 50 (aOR: 2.31,95% CI:1.53-3.50),BMI > 25 units (aOR: 1.57,95% CI: 1.02-2.45). 4) Women subset of asymptomatic cases compared to that of controls: age > 50 (aOR 2.07, 95% CI: 1.14-2.77). Conclusions: 1.Age > 50, being female, BMI > 25 units, genu valgus, are the risk factors for symptomatic OA of the knee 2. Age > 50 and BMI > 25 units are the risk factors for asymptomatic OA of the knee. 3. Being female, BMI > 25 units, genu valgus may be the factors that associated with the development symptoms of OA of the knee.

Keywords: Osteoarthritis, risk factors, knee, symptomatic, asymptomatic

Author: Joewono Soeroso, Leonila F Dans, Maria Lourdes Amarillo, Gina Santoso

Journal Code: jpkedokterangg050030

Artikel Terkait :

Jp Kedokteran gg 2005

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