The efficacy of single-dose albendazole for the treatment of ascariasis
ABSTRACT: This study aims to
assess the efficacy of single-dose albendazole in treating mild, moderate, and
severe ascariasis.
Methods Stool specimens were collected from randomly selected elementary
school children in Suka village, Sumatera Utara, from March to April 2002.
Based on the number of eggs per gram feces (NEPG), samples were categorized as
mild (NEPG < 7000), moderate (NEPG 7000-35,000), or severe (NEPG >
35,000) ascariasis. All subjects then received 400 mg albendazole orally. NEPG
count was repeated on the 7th, 14th, 21st and 28th day after treatment. The
chi-square test was used to compare cure rates between subjects with mild,
moderate, and severe ascariasis. The ANOVA and Kruskal-Wallis tests were
employed to analyze quantitative data.
Results From the 134 specimens collected, we found mild ascariasis in 57
(42.5%), moderate ascariasis in 57 (42.5%), and severe ascariasis in 20 (15%).
There was no significant difference between the three groups in NEPG after
treatment (P>0.05). The cure rate and egg reduction rate on day 28 after
treatment was 100%.
Conclusion A single dose of 400 mg albendazole is effective for the
treatment of mild, moderate, and severe ascariasis.
Keywords: ascariasis,
single-dose albendazole, efficacy
Author: Deddy S Putra, MD; W
Dalimunthe, MD; M Lubis, MD; S Pasaribu, MD; Chairuddin Lubis, MD
Journal Code: jpkedokterangg050073
Artikel Terkait :
Jp Kedokteran gg 2005
- Treatment of taeniasis and cysticercosis with praziquantel and albendazole
- The benefits of progesterone therapy in imminent abortion
- PM10 as Predictor of Ventilation Efficiency of Houses in Relation to Health Effect
- Fatty acids intake among diverse ethnic groups in Indonesia
- The effects of balanced low calorie diet on body composition and serum leptin of obese women
- QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction
- Endoscopical appearances of nonsteroidal anti inflammatory drug (NSAID)- enteropathy
- Role of general practitioner in the management of acute myocardial infarction
- Genotyping of hepatitis B virus from dried and stored serum on filter paper
- Development of bioassay for pathogenecity testing of Ureaplasma urealyticum as part of host-pathogen communication
- Detection of GAD65 autoantibodies of type-1 diabetes using anti-GAD65-abs reagent produced from bovine brain tissue
- The use of ceftriaxone impregnated beads in the management of chronic osteomyelitis
- The correlation between total lymphocyte count and the number of candida colony from the oral cavity in HIV/AIDS patients
- Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment
- Left ventricular diastolic dysfunction in type 2 diabetes mellitus patient without cardiovascular disease: the association with microalbuminuria
- Hormonal contraception as a risk factor for obesity
- Effect of irrigating fluid temperature on core body temperature during transurethral resection of the prostate
- T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases
- Intracranial germ cell tumour with extra cranial extension in a four month old infant – a case report
- Drospirinone: new generation of progestogen
- Implementation of 25-well culture plates for M. tuberculosis drug susceptibility testing in Indonesia
- Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis
- Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities)
- Age, duration of work, noise and vibration in inducing hearing and balance impairments
- Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor