The influence of oral cimetidine administration on creatinine clearance in children with chronic renal failure: A preliminary study
ABSTRACT: Serum creatinine and
creatinine clearance are used to assess glomerular filtration rate but have a
major disadvantage since a variable amount of creatinine is secreted in the
proximal tubule. This may cause an unpredictable overestimation of GFR. Tubular
creatinine secretion can be blocked by cimetidine through competitive
inhibition of cation transport in the proximal tubular luminal membrane.
Objective Cimetidine administration might improve the reliability of
creatinine as a marker of glomerular filtration.
Methods A preliminary study with a one-group pretest-posttest design in
11 children with chronic renal failure. Serum cystatin C level as reference
value was compared with creatinine clearance measured before and after oral
ingestion of cimetidine. The dose of cimetidine was adjusted with the GFR using
Schwartz formula. Statistical evaluation was done with the Wilcoxon signed
ranks test.
Result The mean creatinine clearance before cimetidine administration was
27.4 (SD 14.6) ml/minute/1.73 m2 BSA, and decreased after cimetidine to 21.1
(SD 13,1) ml/minute/1.73 m2 BSA (p=0.015).
Conclusion Oral cimetidine was effective in inhibiting creatinine tubular
secretion. This study could not prove that cimetidine improves the accuracy of
creatinine clearance.
Author: Rosalina D Roeslani,
MD; Partini P Trihono, MD, MM (Paed); Sri Rezeki Harun, MD, PhD
Journal Code: jpkedokterangg050055
Artikel Terkait :
Jp Kedokteran gg 2005
- Treatment of taeniasis and cysticercosis with praziquantel and albendazole
- The benefits of progesterone therapy in imminent abortion
- PM10 as Predictor of Ventilation Efficiency of Houses in Relation to Health Effect
- Fatty acids intake among diverse ethnic groups in Indonesia
- The effects of balanced low calorie diet on body composition and serum leptin of obese women
- QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction
- Endoscopical appearances of nonsteroidal anti inflammatory drug (NSAID)- enteropathy
- Role of general practitioner in the management of acute myocardial infarction
- Genotyping of hepatitis B virus from dried and stored serum on filter paper
- Development of bioassay for pathogenecity testing of Ureaplasma urealyticum as part of host-pathogen communication
- Detection of GAD65 autoantibodies of type-1 diabetes using anti-GAD65-abs reagent produced from bovine brain tissue
- The use of ceftriaxone impregnated beads in the management of chronic osteomyelitis
- The correlation between total lymphocyte count and the number of candida colony from the oral cavity in HIV/AIDS patients
- Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment
- Left ventricular diastolic dysfunction in type 2 diabetes mellitus patient without cardiovascular disease: the association with microalbuminuria
- Hormonal contraception as a risk factor for obesity
- Effect of irrigating fluid temperature on core body temperature during transurethral resection of the prostate
- T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases
- Intracranial germ cell tumour with extra cranial extension in a four month old infant – a case report
- Drospirinone: new generation of progestogen
- Implementation of 25-well culture plates for M. tuberculosis drug susceptibility testing in Indonesia
- Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis
- Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities)
- Age, duration of work, noise and vibration in inducing hearing and balance impairments
- Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor