THE POTENCY OF PIPERINE AS ANTIINFLAMMATORY AND ANALGESIC IN RATS AND MICE
ABSTRACT: The potency of
piperine as anti inflammatory and analgesic were investigated. Piperine was
evaluated for antiinflammatory effect by carrageen-induced rat paw edema.
Sprague Dawley Rats were divided into the control groups were given saline perorally,
piperine groups received doses of 2.5; 5 and 10 mg/kg piperine (peroral) respectively.
This was followed by the administration
of 1 % caragenin through the intraplantar route 30 min after administration
piperine or saline. After the carrageenan
injection was measurement of paw volume and prostaglandin production. The
piperine in doses of 2.5; 5 and 10 mg/kg showed 5.4; 43.8 and 54.8 % inhibition
of paw edema respectively at the end of three hours. The increase in
prostaglandin (PGE2) levels after carrageenan injection was significantly
prevented by preadministration of the piperine at 5 and 10 mg/kg but not piperine at 2.5 mg/kg.
These results suggest that piperine has antiinflammatory properties may be
attributed to inhibition of prostaglandin release. The analgesic activity of
piperine was tested by acetic acid-induced writhing response and hot plate
method in albino mice. The piperine in
doses of 2.5; 5 and 10 mg/kg showed the
percentage of protection from writhing was 1.4; 5.9 and 3.3 % respectively.
However the piperine at 2.5; 5 and 10 mg/kg resulted no significantly analgesic
effect in acetic acid-induced writhing response. In the hot plate model, the
piperine at 2.5; 5 and 10 mg/kg resulted no significantly analgesic effect after
30 min, 1, 2 and 3 h of administration. These results suggest that piperine has
not analgesic properties.
Author: Sri Agus Sudjarwo
Journal Code: jpkedokterangg050014
