Aktivitas Antipiretik Ekstrak Etil Asetat Daun Seligi (Phyllanthus buxifolius Muell.Arg) Pada Mencit Jantan Galur Swiss
ABSTRACT: Seligi (Phyllanthus
buxifolius Muell. Arg) empirically proven to reduce pain and swelling in
joints. The research of analgesic activity and antiinflammatory of seligi
leaves was done, however antipyretic research not be found. The aim of this
research was to examine the effect of ethyl acetate extract from seligi leaves
as antipyretic on white male mice strain Swiss induced with DTP-HB-Hib vaccine.
Ethyl acetate extract of seligi leaves doses of 100, 200 and 400 mg/kg showed
antipyretic effect with values of 18.77 ± 1.99, 24.81 ± 4.34 and 35.39 ± 2.84 %
respectively whereas paracetamol dose of 91 mg/kg have antipyretic effect with
value of 50.38 ± 6.90 %. One way ANOVA test showed no significant difference for p (0.001) <p
(0.05). Significance LSD Post hoc test for paracetamol 91 mg/kg with all seligi
extract and extract seligi dose of 400 mg/kg with seligi extract 100 mg/kg have
significant difference. While seligi extract 400 mg/kg with seligi extract 200
mg/kg and extract seligi 200 mg/kg with seligi extract 100 mg/kg no significant
difference. Ethyl acetate
extract of seligi
leaves can be
developed as source
for active compounds with antipyretic activity.
Penulis: SIWI HASTUTI, SUSI
ENDRAWATI
Kode Jurnal: jpbiologidd160001
